In one of my recent clinical experiences, my preceptor used N-acetylcysteine as an adjunct in the treatment of OCD. I had previously worked for many years on medical-surgical floor and had only seen aceytylcysteine used as a respiratory agent. I thought this was interesting. I was not able to find much research or information on this topic, but there is an article in the Journal of Clinical Psychopharmacology that suggests that "N-acetylcysteine may be a safe and effective option to augment standard treatment in patients with refractory obsessive-compulsive disorder" (Afshar, Roohafza, Mohammad-Beigi, Jahangard, Shokouh, Sadeghi, & Hafezian, 2012).
Has anyone had any success with this?
References
Afshar, H., Roohafza, H., Mohammad-Beigi, H, Haghighi, M., Jahangard, L., Shokouh, P., Sadeghi, M., & Hafezian, H. (2012). N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: a randomized, double blind, placebo-controlled trial.
Journal of Clinical Psychopharmacology, 32(6), 797-803.
doi: 10.1097/JCP.0b013e318272677d.